NM CARES HD is a NIMHD-funded center at UNM, whose mission is to advance the scientific base of knowledge about interventions and solutions to health disparities in New Mexico with a focus on Southwestern indigenous Native American and Hispanic communities. The goals of NM CARES HD are to advance the science of interventions to eliminate health disparities among Southwestern Native American and Hispanic communities; to translate theory-based interventions aimed at eliminating health disparities; to apply community-based participatory research approaches to disparities intervention research; to coordinate UNM disparity-related research resources; to enhance investigators’ abilities to compete for National Institute of Health disparity-related research grants; and to build partnerships between UNM investigators and community collaborators residing in communities suffering health disparities.